Russian researchers propose new ideas for the development of antibiotic drugs

The academician of the Russian Academy of Medical Sciences, A. Vorobiewov, and the researchers of the Institute of Pure Pure Medicine of the Russian Science Center have proposed a new method for the development of new antibiotic drugs. Its scientific mechanism is not to kill the pathogenic microbial bacteria in the body, but the zui greatly stimulates the biological activities of the normal bacterial groups that firmly protect the body, making the pathogenic microorganisms "useless." On the basis of this method, Russian researchers have successfully developed new antibiotic drugs.

It is well known that the problem of antibiotic resistance is very serious, and it has not been easy to choose an effective antibiotic for a disease. In recent years, the scientific community has produced a new term, "anti-pathogenic" drugs, which can either kill bacteria or inhibit the pathogenicity of bacteria.

Currently, there are two main methods for developing new antibiotics:

*, using the principle of group effect regulation. Many pathogenic bacteria can cause disease only after the population density reaches a certain level, that is, they are regulated by group effects. Many bacteria have the ability to secrete one or more autoinducers, and to sense the density of the flora and the surrounding environment by sensing these autoinducers. When the number of bacteria reaches a certain threshold, start the corresponding A regulated expression of a series of genes to regulate the group behavior of the cells. Different types of bacteria have different population effect regulation systems, and many bacteria secrete the same inducer to regulate the behavior of different kinds of bacteria. At present, no new antibiotic drugs have been developed on the basis of this theory.

Second, look for natural compounds that inhibit the effects of bacterial populations, such as plants or seaweeds, which can form natural systems that protect the system. However, it is currently not successful due to the inefficiency of these substances.

Academician Volobyov proposed a third method. This method does not inhibit the group effect of pathogenic bacteria, but zui greatly stimulates the group effect of the normal bacterial population that firmly protects the body. Using this principle, Academician Volobyov successfully developed the strength antibiotic drug “Aktoflol-C” based on the autoregulatory factor of E. coli growth. The experiment found that "Arctorolol-C" can selectively stimulate the growth of normal bacteria in the human body, such as lactobacilli, E. coli and divergent bacteria. At the same time, "Actoflurol-C" can also regulate the immune system and inhibit tumor development.

The research team headed by Academician Volobyov further synthesized "Aktoflol-C" with 17 natural substances. It contains 13 major compounds and its biological activity is more than 10 times that of the bacterial Actrofluorol-C. Researchers believe that "Aktoflol-C" will become a true "anti-pathogenic" drug antibiotic.



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