Stem cell transplantation for the treatment of sequelae of brain injury

Release date: 2006-12-26

Stem cell transplantation for the treatment of traumatic brain injury sequelae 28-year-old Dongmou, caused by car accidents, brain damage, consciousness, and paralysis. The First Affiliated Hospital of the People's Liberation Army General Hospital (304 Hospital) used autologous stem cell transplantation to obtain magical effects for its treatment. Dongmou, who was in bed for half a year, finally stood up under the help of his family and took the first step after rehabilitating. . According to Professor Zhang Zhiwen of the Department of Neurosurgery, they have used this technique to treat 3 patients with sequela of brain trauma, and they have achieved good results. The patient Dong is a Tangshan native. In December last year, he suffered a serious head injury due to a car accident. Although he saved his life after being rescued, he was in bed, and he was awake all day long, incontinent and incontinent, unable to speak and express, and could not recognize his family and friends. The right side of the body is not conscious, relying on the stomach tube to eat every day, the urinary catheter urination. The family carried him to run a number of hospitals, using a variety of methods and drugs for treatment, the condition did not improve. The wife who is going to collapse will bring the last hope, and in March this year, Dong will be carried into the 304 hospital. Dr. Zhang Zhiwen and Dr. Guo Xiaoming from the Department of Neurosurgery performed a detailed examination of Dong’s condition. PET examination showed that the brain tissue of the left frontal lobe of the patient showed a severe low metabolic state, indicating that the brain cells in this area were already inactivated. Even in the state of death, conventional medical treatment has been difficult to work. After repeated consultations with experts, it was decided to use autologous stem cell transplantation to repair the brain function. They collected and amplified the patient's autologous peripheral blood hematopoietic stem cells in three times, and guided the extracted stem cells into the brain injury area with a microcatheter under the guidance of a digital subtraction system. Autologous stem cells continue to differentiate into new nerve cells in the brain, and at the same time activate neural stem cells that are already present and dormant in the brain, and repair the damaged neural network through proliferation, migration, differentiation and the like. After the first treatment, Dong’s sluggish face showed a long-lost smile. After three treatments, he could write with his left hand and actively communicate with others. The right limb recovered consciousness, and the right leg that could not move could be lifted autonomously. The toes can also perform fine movements such as extension and flexion, and the stool can be restored to its own control. The PET review showed that the low metabolic status of the brain tissue in the original injured area was significantly and effectively restored in a short period of time, and the nerve cell activity at this site was close to normal. According to Dr. Guo Xiaoming, who is in charge of Dong’s treatment, after a period of continued treatment and recovery, Dong is expected to be able to walk on his own and live on his own. Professor Zhang Zhiwen, who is engaged in stem cell basic and clinical application research in neurosurgery in the hospital, said that with the development of society, hundreds of thousands of traumatic sequela patients are added every year in China, which brings a heavy burden to families and society. Intervention treatment with stem cell technology has been used. It is the focus and hope of medical research. Studies have confirmed that there are neural stem cells in the adult brain. These endogenous neural stem cells are usually dormant. When activated under specific conditions, the stem cells will simulate the development of the nervous system during the embryonic period, through proliferation, migration, differentiation, etc. The damaged nerve is repaired. Stem cell transplantation for the treatment of traumatic sequelae is to artificially induce and activate endogenous neural stem cells in the brain of the patient to repair the damaged neural network. Autologous stem cell transplantation using cerebrovascular intervention technology, without immune rejection, can avoid the pain of craniotomy, reduce complications, greatly shorten the length of hospital stay, and reduce medical expenses. "Meddy Medical Network"

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