A study published by the University of Hong Kong revealed that some fruits contain "lupulinate" substances and that they are effective in the treatment of head and neck cancer in animal tests. Hong Kong has applied for a patent to use this substance to make anticancer drugs. Yesterday, the reporter interviewed Wen Weiping, Professor of the First Affiliated Hospital of Sun Yat-sen University, who had many years of research in the field of head and neck cancers, on the results of this research. He believes that the results of animal testing will have a long way to go to clinical use. Whether the substance is really effective for the majority of patients can not be commented.
Whether there is curative effect depends on clinical trials
The University of Hong Kong released the study and said that some fruits, including mangoes, grapes and strawberries, contain a substance called "lupulinate," which can effectively suppress and eliminate cancer cells in animal tests. The study believes that if this substance is combined with traditional anti-cancer drugs, head and neck cancers such as nasopharyngeal, nasal and thyroid may be enhanced 40 times the anti-cancer efficacy, which is a major breakthrough in the treatment of head and neck cancer. The University of Hong Kong Medical School said that some Chinese medicines also contain hops ester components. At present, the medical school is applying for a patent and hopes to study the use of this ingredient to refine anti-cancer drugs.
However, the reporter found out yesterday that Wen Weiping, director of the Department of Otolaryngology at the First Affiliated Hospital of Sun Yat-sen University, was flat: “The animal research in basic research will have this new discovery every day, and our clinicians will not be excited at all.†Wen Weiping said that the results of research in Hong Kong are worthy of recognition. However, some experiments on tumor research have made new discoveries. However, whether or not it is effective must be beyond the stage of clinical trials to have the right to speak. Because animal experiments and clinical experiments are very different, many conditions and external disturbance factors in the animal experiment stage can be controlled, but the clinical application to the patient is much more complicated, the patient's condition is not controlled, and each patient is different. "In short, the results of animal experiments have a long way to go into clinical use. Without clinical practice, there is no effect."
Wen Weiping further said that there are three major methods for the treatment of malignant tumors: surgery, radiotherapy, and chemotherapy. In recent years, new methods such as gene therapy, biological therapy, and immunotherapy have emerged. But in general, humans are dealing with tumors. The progress is slow. He mentioned that the United States has invested 10 billion U.S. dollars for basic research on cancer, but a study at the end of last year showed that the overall cancer treatment effect has not improved, and it is introspective that such a research strategy has no problem.
In addition, Wen Weiping also said that the medical community’s recognition of academic research results is more reflected in the publication of the paper. In other words, research results are published in professional publications such as “Science†and “Nature†that have a large impact factor. Accredited.
One-tenth of the incidence of head and neck cancer
The incidence of head and neck cancer in Hong Kong known as the third cancer killer is not low in Guangdong. Wen Weiping said that head and neck cancer is a malignant tumor that occurs in the anatomy of the head and neck, including the tongue, mouth, salivary glands, pharynx, larynx, fistula, and any other part of the head and neck. The incidence of head and neck cancer accounts for about 10% of all malignant tumors in the body. Some of these cancers, such as nasopharyngeal cancer, have a high incidence in Guangdong and are even known as "Cantonese cancer." Each year, there are 5,000 new cases of nasopharyngeal carcinoma in Guangdong, and each year a single case of Zhongshan Medical System treats 2,000 new cases. Why nasopharyngeal cancer is so high in Guangdong? Wen Weiping said that there are many opinions in the medical community, including ethnicity, living habits, and geological conditions. In recent years, some people think that speaking Cantonese may also be related to the high incidence of nasopharyngeal cancer.
Wen Weiping said that in general there are two major categories of carcinogenic factors: heredity and environment. In recent years, the incidence of head and neck cancers and other malignancies has tended to increase due to the environment and poor living habits. Doctors found that head and neck cancers are highly related to smoking. The most dangerous pathogenic factors are tobacco and alcohol. Together, the two are more carcinogenic, and 80% to 85% of head and neck cancer patients have a history of smoking and drinking. Especially for women, this risk is higher.
Head and neck cancer drug treatment is limited
Because of the high incidence of nasopharyngeal carcinoma, Guangdong attaches great importance to the treatment of head and neck cancers including nasopharyngeal carcinoma. Wen Weiping believes that Zhongshan Medical System is not far from the level of clinical treatment of head and neck cancers and international level, especially nasopharyngeal carcinoma. Currently, genetic screening and gene therapy are used to localize nasopharyngeal cancer susceptibility genes. The advanced level.
Today, radiation therapy and chemotherapy have become two important methods for the treatment of head and neck cancer. In the drug treatment segment, Wen Weiping said that the most common squamous cell carcinomas in head and neck cancers have good efficacy in some categories of drugs, but in general, the efficacy of drug treatment for head and neck cancers is not satisfactory. This is because the pathology and pathogenesis of many tumors are unclear and the efficacy of drugs is limited. Therefore, the current treatment of head and neck cancer mostly adopts comprehensive treatment, ie combination of radiotherapy and chemotherapy, and it is rarely used alone.
Chinese Herbs or Curable Head and Neck Cancer The University of Michigan Comprehensive Cancer Center at the American Cancer Research Society's annual meeting in April 2005 announced that a compound extracted from cottonseed oil will help improve the chemotherapy effect of head and neck cancers. These findings will promote the development of a treatment that effectively removes cancer and protects vital organs.
Although some new methods of treating head and neck cancer have enabled some patients to undergo chemotherapy and radiation without the need for surgery, such cancers are often resistant to chemotherapy. When this cancer does not respond to multiple potent drugs, the patient must undergo surgery.
This compound, called gossypol, modulates a protein called Bcl-xL, which acts when cancer cells are attacked, so that these cancer cells can continue to survive when they should die, while cotton Phenol may change this situation. Dr. Shaomeng Wang of the Comprehensive Cancer Center discovered this compound in a component of traditional Chinese medicine. Gossypol comes from cottonseed oil and was used as a male contraceptive in China. Recently, this compound was used for cancer treatment research.
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