1.  Quick Detail:
Â
English name: xylometazoline HCl
English Synonyms:Â Â XYLOMETAZOLINE HYDROCHLORIDE; XYLOMETAZOLIN HYDROCHLORIDE
CAS: 1218-35-5
EINECS Number: 214-936-4
Formula: C16H25ClN2
MW: 280.8361
Â
Boiling point: 394.2 ° C at 760 mmHg
Flash Point: 192.2 ° C
Vapor Pressure: 4.56E-06mmHg at 25 ° C
Appearance: white powder
Assay: 99%
Â
2.  Description:
Â
Xylometazoline (Pronunciation: Zylow-met-TAH-zoleen), also known as xylomethazoline, is a drug which is used as a topical nasal decongestant.It is applied directly into the nose, either as a spray or as drops.
Xylometazoline is marketed under many brand names (see below) but the most common by far is Otrivine. The standard adult solution strength is 0.1% w/V xylometazoline, and the dose for children under 12 is usually 0.05%.
Â
It should not be used for too long a period of time, or rebound effect may occur after discontinuation (see: Rhinitis medicamentosa). It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
3.  Specification:
Molecular Weight :Â 280.84
Molecular Formula :Â C16H24N2.HCl
Â
|
Grades |
IP |
BP/EP |
USP |
|
Description |
A White or almost white, crystalline powder; odorless or almost odorless. |
White to off-white, odorless crystalline powder |
White to off-white, odorless crystalline powder |
|
Solubility |
Freely soluble in Water, in alcohol and in methanol. Practically insoluble in ether |
Soluble in water, freely soluble in alcohol, Sparingly soluble in chloroform, practically insoluble in benzene and in ether |
Soluble in water, freely soluble in alcohol, Sparingly soluble in chloroform, practically insoluble in benzene and in ether |
|
Identification |
a) By IR (KBr) IR spectrum of sample recorded as KBr should exhibit maxima and minima at the same wavelengths as that of the similar preparation of IR spectra of Xylometazoline Hydrochloride working standard. |
a) By IR IR Spectrum of test sample is concordant with IR Spectrum of Xylometazoline Hydrochloride WS. |
a) By IR IR Spectrum of test sample is concordant with IR Spectrum of Xylometazoline Hydrochloride WS. |
| b) by UV An absorbance should be maximum at about 265 nm and minimum at about 257 nm with two inflections at about 270 nm and 275 nm. Absorbance at about 265 nm, about 0.5 |
b) by TLC The principle spot obtained in test solution is similar in position and size to the principle spot in the chromatogram obtained with Xylometazoline Hydrochloride WS. |
b) By TLC The size ,intensity and RF value of principal spot obtained from The test solution correspond to those of the principal spot obtained from the Xylometazoline Hydrochloride WS-solution. |
|
| c) By chemical test A violet color should produce. |
c) Melting Point Melts at 300oC with decomposition |
c) Melting Point Melts above 300oC with decomposition |
|
| d) Test for Chloride A curdy white precipitate should form, which settles in the test tube, indicating presence of chloride ions. |
- |
- |
|
|
pH (5.0 %Â w/V solution in water) |
Between 5.0 to 6.6 |
- |
Between 5.0 &Â 6.6 |
|
Appearance of solution (5.0% in water) |
 |
5.0 %Â solution in water is clear |
 |
|
Acidity/Alkalinity |
 |
Not more than 0.2 ml 0.01 MÂ NaOH is required. |
 |
|
N-(2-Aminoethyl)-4-tert butyl-2,6-xylylacetamide by TLC |
Any spot corresponding to N-(2-Aminoethyl)-4-tert butyl-2,6-xylylacetamide in the chromatogram obtained with the test solution should not more intense than the spot in the chromatogram obtained with the reference solution (0.5%) |
- |
 |
|
Related substances (%, by HPLC) Xylometazoline impurity A Any other impurity Total impurities |
(%, by HPLC) Not more than 0.2Â Not more than 0.1Â Not more than 0.5 |
(by TLC) Not more than 0.2 % Not more than 0.2 % |
 |
|
Iron (ppm) |
Not more than 50 |
- |
 |
|
Sulphates (ppm) |
Not more than 200 |
- |
 |
|
Sulphated ash (%w/w, determined on 1g) |
Not more than 0.1 |
Not more than 0.1 % |
 |
|
Residue on Ignition |
- |
- |
Not more than 0.1 % |
|
Chromatographic Purity |
- |
- |
Complies with standard |
|
Loss on drying (%w/w, determined on 1g at 105oC, for 4Â hr.) |
Not more than 0.5 |
 Not more than 0.5 % |
 Not more than 0.5 % |
|
Assay (%w/w C16H24N2HCl , on dried basis) |
(by Titrimetry) Not less than 99.0 and Not more than 101.0 |
(by Potentiometer) Between 99.0 %Â and 101.0 % |
(by Potentiometer) Between 99.0 %Â and 101.0 % |
| Residual Solvents (by GC, g/g) Methanol Acetone Isopropyl alcohol Tert butyl alcohol Ethyl acetate Benzene Methyl ISO butyl ketone m-Xylene |
  Not more than 3000 Not more than 3000 Not more than 3000 Not more than 3000 Not more than 3000 Not more than 2 Not more than 500 Not more than 890 Not more than 500 |
 |
 |
4.  Applications:
Â
Allergy (hypersensitivity) to xylometazoline or any of the other ingredients
People who have undergone neurosurgery
People who are taking or who have taken drugs for depression called monoamine oxidase inhibitors within the previous 2Â weeks
People taking other similar decongestants
Heart problems
Problems with blood circulation
High blood pressure (hypertension)
Overactive thyroid (hyperthyroidism)
People taking beta-blockers, which are used for high blood pressure (hypertension)
Inflammation of the skin or nose
People who have had their pituitary gland removed by surgery
Children under 12 years of age
Cancer of the adrenal gland (phaeochromocytoma)
A type of eye disease with increased pressure inside the eye called closed-angle glaucoma
Growth Hormne Peptides
| T-A001 | MGF | 2mg |
| T-A002 | PEG MGF | 2mg |
| T-A003 | CJC-1295 with DAC | 2mg |
| T-A004 | CJC-1295 without DAC | 2mg |
| T-A005 | PT-141 | 10mg |
| T-A006 | MT-1(Melanotan-1) | 10mg |
| T-A007 | MT-2(Melanotan-2) | 10mg |
| T-A008 | GHRP-2 | 5mg |
| T-A008 | GHRP-2 | 10mg |
| T-A009 | GHRP-6 | 5mg |
| T-A009 | GHRP-6 | 10mg |
| T-A0010 | Ipamorelin | 2mg |
| T-A0011 | Hexarelin | 2mg |
| T-A0012 | Sermorelin | 2mg |
| T-A0013 | Oxytocin | 1g |
| T-A0014 | TB500 | 2mg |
| T-A0015 | pentadecapeptide BPC 157 | 2mg |
| T-A0016 | Â | 2mg |
| T-A0017 | Triptorelin | 2mg |
| T-A0018 | Tesamorelin | 2mg |
| T-A0020 | Gonadorelin | 2mg |
| T-A0020 | Gonadorelin | 10mg |
| T-A0021 | DSIP | 2mg |
| T-A0022 | Selank | 5mg |
| T-A0023 | Epitalon | 10mg |
Â
Â
|
Peptides |
Specification |
| MGF | 2mg |
| PEG MGF | 2mg |
| CJC-1295 with DAC | 2mg |
| CJC-1295 without DAC | 2mg |
| PT-141 | 10mg |
| MT-1 | 10mg |
| MT-2 | 10mg |
| GHRP-2 | 5mg |
| GHRP-2 | 10mg |
| GHRP-6 | 5mg |
| GHRP-6 | 10mg |
| Ipamorelin | 2mg |
| Hexarelin | 2mg |
| Sermorelin | 2mg |
| Oxytocin | 2mg |
| TB500 | 2mg |
| Pentadecapeptide BPC 157 | 2mg |
| Triptorelin | 2mg |
| Tesamorelin | 2mg |
| Gonadorelin | 2mg |
| Gonadorelin | 10mg |
| DSIP | 2mg |
| Selank |
5mg  |
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Vitexin (CAS No. 3681-93-4)
--------------------------------  Additional Information  -------------------------------
Place of origin :Â China
Brand :Â SMQ
Certificate :Â ISO9001:2008, KOSHER, GMP, SGS
Production capacity :Â 1000 Kilograms/Month
--------------------------------  Delivery Information  ---------------------------------
Packing :Â Foil bag/tin or as your request
Payment :Â T/T, Western Union, MoneyGram
Port :Â Shanghai, Shenzhen, Hongkong
Shipment method :Â EMS, DHL, FeDex, UPS, etc
Leading  time : Within 24 hours after payment
Delivery time :Â Within 6Â business days after payment (door to door service)
--------------------------------  Our Competitive Advantages  ---------------------------
1.Please let me know the items you are looking for, quantity, and the destination country.
2. We send the detailed price of our product and offer the suitable shipping method for your reference.
3. You confirm the order and pay money 100% in advance and send us the detailed address.
4.We will pack your parcel and arrange to shipment according to your requirements
5.Once parcel is sent,I will offer you parcel's picture,tracking number and tracking website.
6.After you receiving parcel,we will offer you best after-sale.
Â
1.  Quick Detail:
Â
English name: xylometazoline HCl
English Synonyms:Â Â XYLOMETAZOLINE HYDROCHLORIDE; XYLOMETAZOLIN HYDROCHLORIDE
CAS: 1218-35-5
EINECS Number: 214-936-4
Formula: C16H25ClN2
MW: 280.8361
Â
Boiling point: 394.2 ° C at 760 mmHg
Flash Point: 192.2 ° C
Vapor Pressure: 4.56E-06mmHg at 25 ° C
Appearance: white powder
Assay: 99%
Â
2.  Description:
Â
Xylometazoline (Pronunciation: Zylow-met-TAH-zoleen), also known as xylomethazoline, is a drug which is used as a topical nasal decongestant.It is applied directly into the nose, either as a spray or as drops.
Xylometazoline is marketed under many brand names (see below) but the most common by far is Otrivine. The standard adult solution strength is 0.1% w/V xylometazoline, and the dose for children under 12 is usually 0.05%.
Â
It should not be used for too long a period of time, or rebound effect may occur after discontinuation (see: Rhinitis medicamentosa). It is on the World Health Organization's List of Essential Medicines, a list of the most important medication needed in a basic health system.
3.  Specification:
Molecular Weight :Â 280.84
Molecular Formula :Â C16H24N2.HCl
Â
|
Grades |
IP |
BP/EP |
USP |
|
Description |
A White or almost white, crystalline powder; odorless or almost odorless. |
White to off-white, odorless crystalline powder |
White to off-white, odorless crystalline powder |
|
Solubility |
Freely soluble in Water, in alcohol and in methanol. Practically insoluble in ether |
Soluble in water, freely soluble in alcohol, Sparingly soluble in chloroform, practically insoluble in benzene and in ether |
Soluble in water, freely soluble in alcohol, Sparingly soluble in chloroform, practically insoluble in benzene and in ether |
|
Identification |
a) By IR (KBr) IR spectrum of sample recorded as KBr should exhibit maxima and minima at the same wavelengths as that of the similar preparation of IR spectra of Xylometazoline Hydrochloride working standard. |
a) By IR IR Spectrum of test sample is concordant with IR Spectrum of Xylometazoline Hydrochloride WS. |
a) By IR IR Spectrum of test sample is concordant with IR Spectrum of Xylometazoline Hydrochloride WS. |
| b) by UV An absorbance should be maximum at about 265 nm and minimum at about 257 nm with two inflections at about 270 nm and 275 nm. Absorbance at about 265 nm, about 0.5 |
b) by TLC The principle spot obtained in test solution is similar in position and size to the principle spot in the chromatogram obtained with Xylometazoline Hydrochloride WS. |
b) By TLC The size ,intensity and RF value of principal spot obtained from The test solution correspond to those of the principal spot obtained from the Xylometazoline Hydrochloride WS-solution. |
|
| c) By chemical test A violet color should produce. |
c) Melting Point Melts at 300oC with decomposition |
c) Melting Point Melts above 300oC with decomposition |
|
| d) Test for Chloride A curdy white precipitate should form, which settles in the test tube, indicating presence of chloride ions. |
- |
- |
|
|
pH (5.0 %Â w/V solution in water) |
Between 5.0 to 6.6 |
- |
Between 5.0 &Â 6.6 |
|
Appearance of solution (5.0% in water) |
 |
5.0 %Â solution in water is clear |
 |
|
Acidity/Alkalinity |
 |
Not more than 0.2 ml 0.01 MÂ NaOH is required. |
 |
|
N-(2-Aminoethyl)-4-tert butyl-2,6-xylylacetamide by TLC |
Any spot corresponding to N-(2-Aminoethyl)-4-tert butyl-2,6-xylylacetamide in the chromatogram obtained with the test solution should not more intense than the spot in the chromatogram obtained with the reference solution (0.5%) |
- |
 |
|
Related substances (%, by HPLC) Xylometazoline impurity A Any other impurity Total impurities |
(%, by HPLC) Not more than 0.2Â Not more than 0.1Â Not more than 0.5 |
(by TLC) Not more than 0.2 % Not more than 0.2 % |
 |
|
Iron (ppm) |
Not more than 50 |
- |
 |
|
Sulphates (ppm) |
Not more than 200 |
- |
 |
|
Sulphated ash (%w/w, determined on 1g) |
Not more than 0.1 |
Not more than 0.1 % |
 |
|
Residue on Ignition |
- |
- |
Not more than 0.1 % |
|
Chromatographic Purity |
- |
- |
Complies with standard |
|
Loss on drying (%w/w, determined on 1g at 105oC, for 4Â hr.) |
Not more than 0.5 |
 Not more than 0.5 % |
 Not more than 0.5 % |
|
Assay (%w/w C16H24N2HCl , on dried basis) |
(by Titrimetry) Not less than 99.0 and Not more than 101.0 |
(by Potentiometer) Between 99.0 %Â and 101.0 % |
(by Potentiometer) Between 99.0 %Â and 101.0 % |
| Residual Solvents (by GC, g/g) Methanol Acetone Isopropyl alcohol Tert butyl alcohol Ethyl acetate Benzene Methyl ISO butyl ketone m-Xylene |
  Not more than 3000 Not more than 3000 Not more than 3000 Not more than 3000 Not more than 3000 Not more than 2 Not more than 500 Not more than 890 Not more than 500 |
 |
 |
4.  Applications:
Â
Allergy (hypersensitivity) to xylometazoline or any of the other ingredients
People who have undergone neurosurgery
People who are taking or who have taken drugs for depression called monoamine oxidase inhibitors within the previous 2Â weeks
People taking other similar decongestants
Heart problems
Problems with blood circulation
High blood pressure (hypertension)
Overactive thyroid (hyperthyroidism)
People taking beta-blockers, which are used for high blood pressure (hypertension)
Inflammation of the skin or nose
People who have had their pituitary gland removed by surgery
Children under 12 years of age
Cancer of the adrenal gland (phaeochromocytoma)
A type of eye disease with increased pressure inside the eye called closed-angle glaucoma
Growth Hormne Peptides
| T-A001 | MGF | 2mg |
| T-A002 | PEG MGF | 2mg |
| T-A003 | CJC-1295 with DAC | 2mg |
| T-A004 | CJC-1295 without DAC | 2mg |
| T-A005 | PT-141 | 10mg |
| T-A006 | MT-1(Melanotan-1) | 10mg |
| T-A007 | MT-2(Melanotan-2) | 10mg |
| T-A008 | GHRP-2 | 5mg |
| T-A008 | GHRP-2 | 10mg |
| T-A009 | GHRP-6 | 5mg |
| T-A009 | GHRP-6 | 10mg |
| T-A0010 | Ipamorelin | 2mg |
| T-A0011 | Hexarelin | 2mg |
| T-A0012 | Sermorelin | 2mg |
| T-A0013 | Oxytocin | 1g |
| T-A0014 | TB500 | 2mg |
| T-A0015 | pentadecapeptide BPC 157 | 2mg |
| T-A0016 | Â | 2mg |
| T-A0017 | Triptorelin | 2mg |
| T-A0018 | Tesamorelin | 2mg |
| T-A0020 | Gonadorelin | 2mg |
| T-A0020 | Gonadorelin | 10mg |
| T-A0021 | DSIP | 2mg |
| T-A0022 | Selank | 5mg |
| T-A0023 | Epitalon | 10mg |
Â
Â
|
Peptides |
Specification |
| MGF | 2mg |
| PEG MGF | 2mg |
| CJC-1295 with DAC | 2mg |
| CJC-1295 without DAC | 2mg |
| PT-141 | 10mg |
| MT-1 | 10mg |
| MT-2 | 10mg |
| GHRP-2 | 5mg |
| GHRP-2 | 10mg |
| GHRP-6 | 5mg |
| GHRP-6 | 10mg |
| Ipamorelin | 2mg |
| Hexarelin | 2mg |
| Sermorelin | 2mg |
| Oxytocin | 2mg |
| TB500 | 2mg |
| Pentadecapeptide BPC 157 | 2mg |
| Triptorelin | 2mg |
| Tesamorelin | 2mg |
| Gonadorelin | 2mg |
| Gonadorelin | 10mg |
| DSIP | 2mg |
| Selank |
5mg  |
Related products
Bodybuilding Steroid Powder/Raw Material Hormone Powder/ Enhances Muscle Steroid Powder:
Â
Â
Â
Epiandrosteron (CAS: 481-29-8)
DHE. A(Dehydroepiandrosteron) (CAS: 53-43-0)
Â
Â
Tadalafi(Ciali) (CAS: 171596-29-5)
Vardenafil (Levitr) (CAS: 224785-91-5)
Â
Weight Loss Powder:
Â
Phentermin Hydrochloride(CAS: 1197-21-3)
L(-)-Carnitine (CAS: 541-15-1)
Rimonabant (CAS: 158681-13-1)
Plant Extract
Tribulus extract (CAS No. 22153-44-2)
Trigonelline (CAS No. 535-83-1)
Curcumin (CAS No. 458-37-7)
Oat Extract (CAS No. 84012-26-0)
Tongkat Ali extract (CAS No. 84633-29-4)
Vitexin (CAS No. 3681-93-4)
--------------------------------  Additional Information  -------------------------------
Place of origin :Â China
Brand :Â SMQ
Certificate :Â ISO9001:2008, KOSHER, GMP, SGS
Production capacity :Â 1000 Kilograms/Month
--------------------------------  Delivery Information  ---------------------------------
Packing :Â Foil bag/tin or as your request
Payment :Â T/T, Western Union, MoneyGram
Port :Â Shanghai, Shenzhen, Hongkong
Shipment method :Â EMS, DHL, FeDex, UPS, etc
Leading  time : Within 24 hours after payment
Delivery time :Â Within 6Â business days after payment (door to door service)
--------------------------------  Our Competitive Advantages  ---------------------------
1.Please let me know the items you are looking for, quantity, and the destination country.
2. We send the detailed price of our product and offer the suitable shipping method for your reference.
3. You confirm the order and pay money 100% in advance and send us the detailed address.
4.We will pack your parcel and arrange to shipment according to your requirements
5.Once parcel is sent,I will offer you parcel's picture,tracking number and tracking website.
6.After you receiving parcel,we will offer you best after-sale.
Â
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