Japanese and American scientists find that hematopoietic stem cells continue to hematopoietic mechanism

Release date: 2017-03-17

The initial life is developed by a stem cell. According to recent research, stem cells exist not only in the fetal period, but also in the organs of adults, "organ-specific stem cells" that can regenerate the organs. These cells have the ability to proliferate indefinitely for a lifetime, but in general, they are mostly in a "dormant state" due to strict restrictions; when the organ is damaged, etc., proliferation and differentiation occur as needed. Stem cells "sleep" only in special circumstances, and this environment is called "é¾›".

In our blood, there are "hematopoietic stem cells" that make various blood cells such as red blood cells, white blood cells, and platelets. Hematopoietic stem cells mainly exist in the epiphysis. It has been known before that the mesenchymal stem cells that form the source of bones are the kind of "cell rafts", but the specific mechanism is unclear.

The joint research team of the Graduate School of Kyushu University and the University of Albert Einstein in the United States found for the first time in the world that mesenchymal stem cells can also be classified according to genetic and protein expression, and they can form various cytokines (maintaining stem cell hematopoiesis). Substance). This finding opens up a gap in understanding the complex mechanisms that maintain stem cell function in life, and may contribute to the development of new ways to efficiently proliferate hematopoietic stem cells and even accelerate the development of regenerative medicine.

The results were published electronically in the February 20, 2017 issue of Nature Cell Biology.

Source: Ministry of Science and Technology

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