French researchers reported in a new issue of the journal Science Translational Medicine that they used gene therapy in the laboratory to treat cynomolgus monkeys suffering from Parkinson's disease, improving the athletic ability of cynomolgus monkeys without common occurrence. Side effects caused by therapy.
The experimental treatment was carried out by researchers at the Henry-Montdo Hospital in Paris, France. They implanted three genes in a cynomolgus monkey with Parkinson's disease, prompting specific cells in their brain to secrete the chemical dopamine. After receiving gene therapy, the monkey's exercise capacity was greatly improved, and the treatment effect was maintained for 44 months. Preliminary results show that this gene therapy is safe in animals.
Researchers say that human trials have begun, and six patients with Parkinson's disease have begun to receive this gene therapy a year ago. The effects are “very encouraging†from the side effects of improving exercise capacity and reducing encephalitis. However, because there are still some technical problems to be solved, this gene therapy still has a long way to go from clinical application.
In an evaluation of the study, Fatah Nahab, director of the Department of Movement Disorders at the Miller School of Medicine at the University of Miami, said that dyskinesia and hand and foot tremor are the main symptoms of Parkinson's disease. These symptoms are mainly due to a severe lack of brain in patients. Caused by dopamine. But patients also have other symptoms, such as dementia, depression, anxiety, heart disease, loss of taste and constipation, and most of these symptoms are not related to dopamine. Nahab said that gene therapy currently only addresses the problem of dopamine deficiency and does not solve other problems.
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